Shinigami's intention in creating Kid can also be seen as a 'heroic' example of this, as he also fully expected his heir to be able to kill Asura.
Soul Eater has Crona trained by Medusa specifically to become a being capable of killing Kishin Asura. His isolation as a child resulted in him having little contact with sentient creatures other than a fragment of Endless who, despite not having quite enough control over him to be a Man Behind the Man, convinced him that the sole reason he existed was to trigger the world-ending 'Overdrive' explosion. In Rave Master it's the Big Bad, Lucia who fits the bill. Once Princess Tutu threatens to steal Mytho, Kreahe is willing to do anything the Raven asks if it helps her get him for herself. The Raven tells Kraehe that she's a crow born with a " hideous human body", and as such, no human but the Prince could ever love her. Princess Kraehe in Princess Tutu is an unusual case, since she was raised with a specific purpose in mind as part of the Raven's Evil Plan, but rather than teaching her to hate Mytho, he sets her up to fall desperately in love with him. His father Endeavor specifically married his mother to produce an heir able to surpass All Might as the Number One Hero. In the second season of the anime, Nova is one of these, aimed at Hikaru. In Magic Knight Rayearth The Magic Knights were specifically summoned to Cephiro by Princess Emeraude to kill her. The protagonist even comments that she is not a person, merely a "phantom of mother." Add a lifetime of Training from Hell and a Parasol of Pain, and cut her loose with a list to hunt every last one down. The protagonist was concieved in jail solely as a means for her mother to take revenge on those who hurt her and her family. Lady Snowblood has an extreme example. This backfires when Hakaider repeatedly spares Kikaider, even attacking other Monsters of the week, so that he could eventually fight - and defeat - Kikaider at his strongest, bringing the most meaning to his (Hakaider's) existence. Hakaider, Kikaider's Evil Counterpart. Schrodinger from Hellsing, who was created for the sole purpose of poisoning Alucard. ( Etherious Natsu Dragneel) to not only accomplish Zeref's original goal, but also to create the one being capable of killing his older brother. 
Natsu was revived as the potentially strongest demon E.N.D. However, he can (in theory) be killed - the demons of the Book of Zeref were originally created to do so but none had the power to do it. As long as he valued life, everything around him would die - and they made him immortal to boot, as well. His studies angered the gods, who cursed him. Natsu was originally the deceased younger brother of Zeref, who delved into black magic in order to find out a way to revive him. He does meet Goku face-to-face near the end of the saga, but restrains himself from attacking, because that isn't what he wants to do. However, he absolutely refused to engage in any violence against anyone or anything other than his designated target until the threat of Cell presented itself.
Being purely robotic (17 and 18 are Cyborgs, made by upgrading a pair of human siblings), 16 was initially unable to overcome his core programming. The last one is bizarre when combined with 16's love of life and extremely calm demeanor. 19 remains faithful to Dr Gero and 16, while he doesn't seem to lament the loss of his creator, still wants to kill Goku. In Dragon Ball Z, all the androids were made and somehow designed to kill Goku in order to avenge the Red Ribbon army. Inverted as well though, since the guy who raised him, raised him as his son. 
Rin from Blue Exorcist is allowed to live so he can take down his father, Satan. The process of giving him this power stripped him of all higher brain functions, so he's not very useful for anything else. In Bleach Wonderweiss's Resurección turned out to be specifically designed by Aizen to counter Genryūsai Yamamoto's zanpakuto Ryujin Jakka by absorbing its flames. This is aided by him gaining the ability to transform into a Titan, with it hinted his father injecting him with a mysterious substance is the cause. Eren Yeager, the main character from Attack on Titan becomes one as a result of witnessing a Titan devour his mother, swearing to exterminate every last one of them. Itona of Assassination Classroom was trained and genetically modified by Shiro specifically to kill Korosensei, to the point where every time he fails, he almost dies. They may have also groomed Jinnosuke, Afro's old best friend, for this specific purpose. The bad guys constructed a robot version of Afro able to mimic all of his abilities specifically to kill him.
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